植物病原真菌聚酮類(lèi)次級(jí)代謝產(chǎn)物研究進(jìn)展

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中圖分類(lèi)號(hào)：S432.1;S763 文獻(xiàn)標(biāo)志碼：A 文章編號(hào)：1000-2006（2025）04-0285-08

Abstract：During host-pathogen interaction，pathogenic fungi facilitate host invasionandpathogenesis throughthe productionof secondary metabolites.Fungal polyketides，catalyzed by polyketide synthase（PKS），representthe most abundantclassof bioactivemetabolitesinfungi，theycanestablishphytopathogenic fungi succesful infections，by synthesizing keypigments，virulence factors，and mycotoxins to evade and disrupt hostplant immune mechanisms.This reviewsystematicallyexamines thestructural characteristics，clasification，biological functions，and metabolic regulation offungal typeIPKS.Furthermore，we highlight recent advances in characterizing polyketide compounds and theirbiosyntheticgeneclusters inplant-pathogenic fungi.Potential futureresearchdirectionsforfungalpolyketidesare prospected，with emphasisontheirrole infungal pathogenicity.Collctively，thisworkaims toprovidenovelinsightsand methodologicalframeworksfor elucidatingpathogenicmechanismsoffungal infectionsanddeveloping targeteddisease control strategies.

Keywords：filamentous fungi；polyketide;gene cluster;pathogenic function；regulation mechanism

真菌在生命活動(dòng)中會(huì)產(chǎn)生許多分子量低、具有生物活性的物質(zhì)，被稱(chēng)為次級(jí)代謝產(chǎn)物[1]，雖然次級(jí)代謝產(chǎn)物對(duì)其生存并非必要，但在生態(tài)位適應(yīng)、繁殖、耐脅迫、競(jìng)爭(zhēng)及互作等方面具有重要意義[2]。（剩余21762字）