基于網(wǎng)絡(luò)藥理學(xué)及分子對(duì)接探討復(fù)方扶芳藤合劑治療慢性肺心病作用機(jī)制

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[關(guān)鍵詞］慢性肺心?。粡?fù)方扶芳藤合劑；網(wǎng)絡(luò)藥理學(xué)；分子對(duì)接；作用機(jī)制[中圖分類(lèi)號(hào)］R285 [文獻(xiàn)標(biāo)志碼］A [文章編號(hào)]0256-7415（2025）12-0187-08DOl：10.13457/j.cnki.jncm.2025.12.035

Exploration of Mechanism of Compound Fufangteng Mixture in Treating Chronic Pulmonary Heart Disease Based on Network Pharmacology and Molecular Docking

HUANG Qingyu1，BAO Yanbo2，LIU Pengye3，HUANG Yewen2，GONG Shengwen1

1.RuikangHospitalAfiliatedtoGuangxi UniversityofChineseMedicine，NanningGuangxi530l1，China；.GuangxiUnivestyof

ChineseMedicine，NanningGuangxi530o01，China；3.TheFirstAflitedHospitalofGuangxiUniversityofChineseMedicine，

Nanning Guangxi 530022，China Abstract：Objective：To explore the mechanism of Compound Fufangteng Mixture in treating chronic pulmonary

heart disease （CPHD）based on network pharmacology and molecular docking.Methods：Active components and

potentialtargets of Compound Fufangteng Mixture were screened using the TCMSPdatabase and HERB website.Disease

targets of CPHD were identified through the GeneCards and OMIM-NCBI databases.Common targets of the drug and

disease were analyzedusing the STRING platform to construct aprotein-protein interaction（PPI）network and identify core targets.GO and KEGG enrichment analyses wereperformed using the DAVID database.Finally，molecular docking was conducted to validate the interactions between five main active componentsand fivecore targets.Results： Network pharmacologyanalysis identified 2O active components in Compound Fufangteng Mixture，including quercetin， kaempferol，7-O-methylisomucronulatol，formononetin，andisorhamnetin.A totalof 186 common targetswere identified between the drug and CPHD，including AKT1，TP53，TNF，JUN，and VEGFA.The common targets were enriched in 2702GO terms and18O pathways，such as the IL-17 signaling pathway，TNF signaling pathway，MAPK signaling pathway，and Th17cell diffrentiation signaling pathway.Molecular docking results showed strong binding affinitiesbetween quercetin and TP53/VEGFA，kaempferol and TP53，and isorhamnetinand VEGFA.Conclusion： Compoud Fufangteng Mixture may treat CPHD through active components such as quercetin，kaempferol，and isorhamnetin acting on core targets and regulating signaling pathways like IL-17，TNF，and MAPK，thereby exerting anti-inflammatory and antioxidant effects.

Keywords：Chronic pulmonary heart disease；Compound Fufangteng Mixture；Network pharmacology; Molecular docking；Mechanism

慢性肺源性心臟病簡(jiǎn)稱(chēng)慢性肺心病，是由慢性呼吸系統(tǒng)疾病、肺血管病變或胸廓畸形引起肺循環(huán)阻力增加，導(dǎo)致肺動(dòng)脈高壓和右心室結(jié)構(gòu)與功能改變的臨床綜合征，最終可發(fā)展為心力衰竭。（剩余7623字）