基于網(wǎng)絡(luò)藥理學(xué)及分子對(duì)接技術(shù)分析蛇床子治療早泄作用機(jī)制

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[中圖分類號(hào)］R285 [文獻(xiàn)標(biāo)志碼］A [文章編號(hào)]0256-7415（2025）09-0212-08

DOI：10.13457/j.cnki.jncm.2025.09.038

Analysis of Therapeutic Mechanism of Cnidium Monnieri in Treating Premature Ejaculation Based on Network Pharmacology and Molecular Docking Technology

ZHANG Hong1，LIU Yezi，GAO Yating1，HUANG Shuxian2，OU Yangfan1，XIE Zuogang1 1.WenzhouHospitalofIntegratedTraditoalChineseandWesteMedicine，WenzhouZhejang325oo，China；.TheSecondPeople's Hospital of Longwan District of Wenzhou，Wenzhou Zhejiang 325ooO，China

Abstract：Objective：To analyze the main targets and therapeutic mechanisms of Cnidium Monnieri in treating premature ejaculation using network pharmacology and molecular docking technology.Methods：The main active components and their targets of Cnidium Monnieri were obtained from the TCMSP database.Disease-related targets were retrieved from the DrugBank and GeneCardsdatabases.A Cnidium Monnieri-active components-intersecting gene network was constructed.The protein-protein interaction （PPI） network was obtained using the String database.Gene Ontology（GO）analysisand Kyoto Encyclopedia of Genes and Genomes（KEGG）pathway analysis were performed using the DAVID database，folowed by molecular docking.Results：A total of 2O activecomponents and 10 key targets of Cnidium Monnieri were identified.GO functional enrichment analysis showed that Cnidium Monnieri mainly regulates functions in the membrane，nucleus，cytoplasm，plasma membrane，transferase，receptor，and kinase. KEGG pathway enrichment analysis indicated that Cnidium Monnieri is involved in the PI3K-Akt signaling pathway， thyroid hormone signaling pathway，cancer pathway，and prostate cancer pathway.Molecular docking results showed stable binding of Cnidium Monnieri'sactive component（Osthole）to targets such as AKT1，ESR1，EGFR，and JUN.

Conclusion：Cnidium Monnieri may exert its therapeutic effects by Osthole on premature ejaculation by acting on targets such as AKT1，ESR1，EGFR，and JUN through the regulation of the PI3K-Akt signaling pathway，thyroid hormone signaling pathway， cancer pathway，and prostate cancer pathway.

Keywords：Premature ejaculation；Cnidium Monnieri；Network pharmacology；Osthole； Signaling pathways

早泄是常見的男性性功能障礙疾病，表現(xiàn)為較短的陰道內(nèi)射精潛伏時(shí)間，缺乏射精控制能力，對(duì)患者和（或）性伴侶造成困擾和人際交往障礙。（剩余8374字）