Lefamulin：一種新型人用截短側(cè)耳素類抗菌藥物的臨床藥學(xué)研究

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摘要：Lefamulin是全球首個(gè)靜脈和口服劑型的人用截短側(cè)耳素類抗菌藥物，具有獨(dú)特的作用機(jī)制，與其他臨床用抗菌藥物不易產(chǎn)生交叉耐藥性。對社區(qū)獲得性肺炎、皮膚軟組織感染以及性傳播疾病的常見病原體有良好的抗菌活性。本文就lefamulin的作用機(jī)制、耐藥機(jī)制、抗菌活性以及臨床使用等方面進(jìn)行綜述。

關(guān)鍵詞：截短側(cè)耳素；lefamulin；抗菌活性；臨床藥學(xué)

中國分類號(hào)：R978.1        文獻(xiàn)標(biāo)志碼：A

Clinical pharmacology of lefamulin-a new pleuromutilin class

of antibiotics for human use

Xue Feng1， Ma Xu-zhu2 and Zheng Bo1

（1 Institute of Clinical Pharmacology， Peking University First Hospital， Beijing 100034;

2 General Internal Medicine， Beijing Tsinghua Changgung Hospital， Tsinghua University， Beijing 102218）

Abstract    Lefamulin， the first semisynthetic pleuromutilin antibacterial for oral and intravenous administration in patients， has a unique mechanism against bacteria and does not show cross-resistance with other antimicrobials. In vitro studies have demonstrated that lefamulin has potent activity against a variety of bacteria that cause community-acquired pneumonia， skin and soft tissue infections and sexually transmitted diseases. This article reviews the mechanism， drug resistance， antibacterial activity， and clinical use of lefamulin.

Key words    Pleuromutilin; Lefamulin; Antimicrobial activity; Clinical pharmacology

截短側(cè)耳素類抗菌藥物早在20世紀(jì)70年代就被作為獸用抗菌藥物，近年來將其作為人用抗菌藥的研究趨熱。（剩余6475字）