兒童大環(huán)內(nèi)酯類(lèi)耐藥的重癥肺炎支原體肺炎早期識(shí)別與治療

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Early identification and treatment of macrolide-resistant severe Mycoplasmal pneumoniaepneumoniainchildren

YU Man122， YE Leping1

1.DepartmentofPediatricRespiratoryMedicine，Children'sMedical Center，Peking UniversityFirst

Hospital，Beijing102627，China

2.Department of Pediatrics，BeijingPinggu Hospital，Beijing1012oo，China

Corresponding author： YE Leping， Email： yeleping@bjmu.edu.cn

【Abstract】Mycoplasmal pneumoniae pneumonia （MPP） is a common respiratory disease in children.The incidence of severe MPP （SMPP） has increased and the situation is critical due to a variety offactors such as declining herd immunity，macrolide antibiotic resistance，delayed diagnosis and treatment，and mixed infection.Most children with SMPP have severe clinical symptoms and a long course of disease. SMPP is prone to serious complications such as lung consolidation， atelectasis，plastic bronchitis， necrotizing pneumonia，and extrapulmonary manifestations， leaving behind chronic lung diseases such as bronchiectasis and bronchiolitis obliterans， which affect the quality of children’s life. Children who are likely to develop SMPP should be given high attention. Early identification of SMPP with macrolide-resistant can be achieved by clinical manifestations， relevant laboratory tests，lung imaging，and bronchoscopic changes，and individualized treatment plan can be adjusted in time. Early diagnosis and effective treatment can alleviate the pain of children，shorten the courseofdisease，and reduce the incidenceof severe diseases.This article reviews the early identificationand treatment of severemacrolide-resistantMPPinchildren.

【Keywords】Mycoplasma pneumoniae； Macrolide antibiotics； Drug resistance； Severe pneumonia； Early identification； Treatment

肺炎支原體肺炎（Mycoplasmalpneumoniaepneumonia，MPP）由肺炎支原體（Mycoplasmapneumoniae，MP）感染引起，為兒童社區(qū)獲得性肺炎的常見(jiàn)疾病，好發(fā)于學(xué)齡期以上的兒童，但近年來(lái)，在3月齡以上的嬰幼兒中發(fā)病亦不少見(jiàn)[]。（剩余19358字）