雄激素性禿發(fā)患者對(duì)酮康唑洗劑和二硫化硒洗劑過敏風(fēng)險(xiǎn)分析

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中圖分類號(hào)：R758.71 文獻(xiàn)標(biāo)志碼：A DOI：10.11958/20250019

Abstract：ObjectiveTo analyze the incidence of contact allrgic reactions to ketoconazole shampoo and selenium sulfideshampooin patients with androgenetic alopecia （AGA）.MethodsAretrospectiveanalysis wasconducted on 683 AGA patients.Basedonmedical records，dermoscopy findings，fungal examinations and patch testresults，thenumberof patientswith seborheic dermatitis，Malassezia-positivecasesand contactalergyto ketoconazoleandseleniumsulfide shampoos were recorded.ResultsThe incidence of seborrheic dermatitis in AGA patients was 65.59 % ，and the Malasseziapositive rate was 42.02% . The allergy rate to ketoconazole shampoo in AGA patients was 34.70% ，whichwassignificantly higher than the 25.62% allergy rate to selenium sulfide shampoo （ P<0.01 ）.InAGA patientswith concomitant seborrheic dermatitisandMalasseziapositivity，theallrgyrate to ketoconazolelotion was higherthan that toseleniumsulfidelotion （ P<0.05 ）.Thepositivity rate ofMalassezia was 45.98% in seborrheic dermatitispatients，which was higher than that of the （204號(hào) 34.47% in non-seborrheic dermatitis patients （ P<0.01 ）.Conclusion In patients with AGA，ketoconazole shampoo carries ahigher allrgyriskcompared toselenium sulfide shampoo.Long-term use of antifungal shampoosshould beavoided in patientswith AGA and conduct patch tests for drug detection when necessary.

KeyWords：alopecia; dermatitis，seborrheic; disulfides; selenium; ketoconazole;dermatitis，contact

雄激素性禿發(fā)（androgenetic alopecia，AGA）是一種非瘢痕性模式性脫發(fā)，是最常見的脫發(fā)類型，特征為脫發(fā)區(qū)域毛囊漸進(jìn)性微小化及減少[1]。（剩余6261字）