18F-PSMA-1007PET/CT的SUVmax和SUVmean參數(shù)對(duì) 前列腺癌診斷及病情進(jìn)展的預(yù)測(cè)價(jià)值

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關(guān)鍵詞：前列腺腫瘤;正電子發(fā)射斷層顯像計(jì)算機(jī)體層攝影術(shù);8F-PSMA-007;診斷;SUVmax;SUVmean中圖分類(lèi)號(hào)：R84.42，R737.25，R445 文獻(xiàn)標(biāo)志碼：A DOI：0.958/20250665

Abstract：ObjectiveTo explorethe predictive value of maximum standardized uptake value （SUVmax）and mean standardized uptake value （SUVmean） parameters in 18F? -prostate specific membrane antigen-1Oo7 positron emission tomographyl computed tomography （ 18F? -PSMA-1OO7 PET/CT） for the diagnosis and disease progresson of prostate cancer （PCa）.MethodsEighty patients with suspected PCa who underwent 18F -PSMA-10O7 PET/CT examination in the hospital were selected and divided into the PCa group （49 cases）and the non-PCa group（31 cases）according to thebiopsy pathological results.The 18F -PSMA-1007 PET/CT parameters werecolectedinthe two groupsofpatients atadmission，including SUVmaxandSUVmean.The prostate specific antigen（PSA）and prostatecancerhistological grade（GLEASON）score werealsocolected inpatients ofthePCa group at admission and 3 months after admission.The diagnostic efficiency of 18F -PSMA-10O7 PET/CT parameters on PCa was analyzed by receiver operating characteristic （ROC） curve.The correlation between 18F -PSMA-1007 PET/CT parameters of patients in the PCa group at admision and PSA，GLEASON score was analyzed by Pearson method.ResultsThe SUVmax and SUVmean in the PCa group were higher than those in the non-PCa group P<0.05 ）.ROC curve analysis showed that the areas under the curves （AUCs）of SUVmax and SUVmean were O.887 and O.843 respectively，the sensitivities were 80.65% and 83.87% ，and the specificities were 87.76% and 73.47% respectively. The PSA and GLEASON score were lower 3 months after admission than those at admission in the PCa group（ P<0.05 ）.Pearson correlation analysis showed that the SUVmax and SUVmean of patients in the PCa group at admission were positivelycorrelated with PSAand GLEASONscore atadmissionand3 months afteradission（ P< 0.05）. Conclusion SUVmax and SUVmean parameters of 18F -PSMA-1OO7 PET/CT have high predictive value for the diagnosis and disease progression of PCa.

Key words：prostatic neoplasms;positron emission tomography computed tomography; 18 F-PSMA-1007;diagnosis; SUVmax; SUVmean

前列腺癌（PCa）是男性泌尿系統(tǒng)常見(jiàn)的惡性腫瘤之一，目前我國(guó)PCa發(fā)病率雖低于歐美國(guó)家，但隨著近年來(lái)人口老齡化、生活方式改變及前列腺特異抗原（PSA）篩查的普及而呈逐年上升趨勢(shì)[1]。（剩余10582字）