內(nèi)皮細胞損傷及其功能障礙在動脈粥樣硬化中作用的研究進展

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中圖分類號】 R 543.5 【文獻標識碼】 ADOI：10.12114/j.issn.1007-9572.2024.0440

【Abstract】Cardiovascular disease is a prevalent condition characterized bya high incidence rate and mortality. Atherosclerosis（AS）servesastheunderlying pathologicalmechanism fornumerous cardiovasculardiseases，primarilymarked bylipidaccumulationand plaque formation withinarterial wals，therebyimpactingtissueororgan ischemiaornecrosis.This comprehensivearticledelvesintothepivotalroleofendothelialcells（ECs）inatheroslerosis，elucidatingtheirmechanismsof injuryanddysfunction，aswellastheir interactions withmacrophagesandvascularsmoothmusclecells（VSMCs）duringthis proces.ThefindingspresentedhereinunderscorethecriticalinvolvementofECsinASpathogenesis，emphasizingthatmitigating damagetothesecellsandpreservingtheirfunctionalitycanpotentiallyameliorate theonsetandprogresionofAS.Ouraimis to provide novel therapeutic avenues for AS.

【Key words】 Atherosclerosis；Endothelial cells；Dysfunction；Energy metabolism

心血管疾病是全球人口死亡的主要原因，而動脈粥樣硬化（AS）是多種心血管疾病的病理基礎(chǔ)，如高血壓、冠心病、心肌梗死、缺血性卒中等[1]。（剩余24653字）