神經(jīng)肌肉疾病患者睡眠呼吸障礙的診治進(jìn)展

【摘要】 神經(jīng)肌肉疾病易于合并睡眠呼吸障礙，早期診斷和干預(yù)睡眠呼吸障礙對慢性神經(jīng)肌肉疾病的管理具有重要價值。本文回顧分析了神經(jīng)肌肉疾病患者合并睡眠呼吸障礙的機(jī)制、臨床表現(xiàn)、診斷方法及治療進(jìn)展。近年來雖然便攜式睡眠監(jiān)測設(shè)備不斷發(fā)展，但對此類患者的診斷價值尚未完全明確，仍需要更多的關(guān)注和研究。

【關(guān)鍵詞】 神經(jīng)肌肉疾??；睡眠呼吸障礙；多導(dǎo)睡眠監(jiān)測；便攜式睡眠監(jiān)測；無創(chuàng)正壓通氣；診斷；治療

【中圖分類號】 R 746 R 563.8 【文獻(xiàn)標(biāo)識碼】 Ａ DOI：10.12114/j.issn.1007-9572.2022.0266

丁啟迪，曹照龍，韓芳. 神經(jīng)肌肉疾病患者睡眠呼吸障礙的診治進(jìn)展［J］. 中國全科醫(yī)學(xué)，2022，25（33）：4203-4206 .［www.chinagp.net］

DING Q D，CAO Z L，HAN F. Advances in the diagnosis and treatment of sleep-disordered breathing in neuromuscular disease［J］. Chinese General Practice，2022，25（33）：4203-4206.

Advances in the Diagnosis and Treatment of Sleep-disordered Breathing in Neuromuscular Disease DING Qidi，CAO Zhaolong，HAN Fang*

Department of Respiratory and Critical Care Medicine，Peking University People's Hospital，Beijing 100044，China

*Corresponding author：HAN Fang，Professor，Chief physician；E-mail：hanfang1@hotmail.com

【Abstract】 Sleep-disordered breathing（SDB） occurs frequently in neuromuscular disease（NMD） patients，and early diagnosis and treatment of which are of great value in the management of NMD. We reviewed the advances in pathogenesis，clinical manifestations，diagnostic and treatment modalities of SDB in NMD. It is noteworthy that although the development of portable sleep monitoring devices is ongoing，the diagnostic value of them for such patients has not been fully clarified，and more attention and further research are still needed.

【Key words】 Neuromuscular disease；Sleep-disordered breathing；Polysomnography；Portable monitor；Noninvasive positive pressure ventilation；Diagnosis；Treatment

神經(jīng)肌肉疾病（neuromuscular disease，NMD）是以神經(jīng)肌肉功能受損、肌力減退、運(yùn)動耐力下降為主要表現(xiàn)的一大類疾病，主要累及下運(yùn)動神經(jīng)元，如腦干運(yùn)動神經(jīng)元、脊髓前角、神經(jīng)根、神經(jīng)肌肉接頭、周圍神經(jīng)等［1］。（剩余11369字）