復(fù)方青黛膠囊聯(lián)合阿維A膠囊對銀屑病患者血清 炎性因子及皮膚屏障功能的影響

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Effect of compound Qingdai capsules combined with Avia capsules on serum inflammatory factors and skin barrier functioninpatients with psoriasis， ， ，.Departmentof Dermatology，HenanHongliHospital，Henan4534o0，Chin

【Abstract】Objective To explore the application effct of the combination of compound Qingdai capsules and Aviacapsules in the treatment of psoriasis patients.MethodsAcording to the random number table method， 94 psoriasis patientsadmited to our hospital from December 2O21 to December 2023 were divided into two groups，with 47 patients in each group.Both groups kepta light diet and avoidedbad living habits.On this basis， thecontrol group was treatedwith AviaA capsule，and the observationgroup was treated with traditional Chinese patent medicines and simple preparationscompound Indigo Naturalis capsuleon the basisof thecontrol group. Both groups were treated continuously for8 weeks.Compare theclinical eficacy，serum inflammatorycytokine levels，skin barier function，immune function，psoriasisareaand severity index （PASI） scores，and incidenceof adverse reactions between the two groups.ResultsThe total efectiverateand skin barrer function indicatorsof the observation group after treatment were higher than those of the control group （ P <0.05）.The immune function of the observation group was better than that of the control group after treatment （ P <0.05）. The levels of serum inflammatory factors andPASI scores in the observation group were lower than those in thecontrol group after treatment （ P <0.05）.There was no difference in adverse reactions between the two groups （ P>0.05 ）.Conclusion Compared with the single use of Avia capsules，the addition of Compound Qingdai Capsules has a significant therapeuticeffectonpsoriasispatients，whichisbeneficialforreducingseruminflammatoryfactorlevels，improving skin barrier function，enhancing immune function，reducing PASI score，and has higher safety.

【Key words】Psoriasis；Compound Qingdai capsules；Avia capsules；Serum inflammatory factors； Skinbarrier function；Immunologic function

銀屑病是一種慢性炎癥皮膚病，主要是由遺傳、環(huán)境及藥物感染等多種因素相互作用引起的慢性鱗屑性皮膚病，臨床表現(xiàn)為皮膚出現(xiàn)紅斑，并覆蓋銀白色鱗屑，皮膚瘙癢、干燥等，全身均可發(fā)病以頭皮，四肢伸側(cè)較為常見，該病病程較長，易復(fù)發(fā)，經(jīng)久難愈，對患者身心健康和日常生活影響較大。（剩余6177字）