基于網(wǎng)絡藥理學探討穿心蓮內(nèi)酯的潛在抗炎機制

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Analysis of the potential anti-inflammatory mechanism of andrographolide based on network pharmacology WangHua，LiuWei.

【Abstract】ObjectiveTo explore the multiple-target and multipath anti-inflammatory mechanism of Andrographolide （AP）basedon network pharmacology.MethodsRetrieve the potential target proteins of AP with theaid ofthe DRAR-CPI server and GeneCards database，establish the corresponding target network of key active componentswas drawn by using Cytoscape.Verify the activityof the screenedcore targets through molecular docking，and the GOand KEGG enrichment analysisof potential targetswascarriedout byusingWebGestalt. ResultsTheanalysis foundthat92 targetsare involvedintheanti-inflammationofAP，of whichPGR，AKT1， NR3C1，HMOX1 and MAPK1 showed strong bindingactivity，and the signalling pathways enrichment analysis showed thatandrographolideanti-inflammatoryefectmainlyinvolved33Osignallingpathways，suchasPlatinum drugresistance，Prostatecancer，Apoptosis，Progesterone-mediated ocytematuration，Thyroid hormone signalling pathway and soon.ConclusionThis study shows that AP hasa multi-targetand multi-channel anti-inflammatory effct，which provides ideas and clues for its further clinical application and in-depth research and development.

【Key words】 Andrographolide;Network pharmacology；Anti-inflammatory agents；Molecular docking

穿心蓮內(nèi)酯（Andrographolide，AP）為爵床科植物穿心蓮Andrographis paniculata （Burm.f.） Nees的主要二萜內(nèi)酯類活性成分之一，目前在臨床上廣泛應用的品種有穿心蓮內(nèi)酯片、穿心蓮內(nèi)酯滴丸、穿心蓮內(nèi)酯膠囊和蓮必治注射液等，具有顯著的清熱解毒，抗菌消炎的功效。（剩余8623字）