非編碼RNA對(duì)骨關(guān)節(jié)炎的調(diào)控機(jī)制及中藥干預(yù)研究進(jìn)展

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中圖分類號(hào)R965 文獻(xiàn)標(biāo)志碼A 文章編號(hào) 1001-0408（2025）14-1819-06

DOI 10.6039/j.issn.1001-0408.2025.14.23

ABSTRACTOsteoarthritis（OA）isachronicdegenerativediseasecharacterizedprimarilybythedegenerationofarticular cartilage，withitspathogenesisinvolvingamultifactorialinterplayofinflammatoryresponses，chondrocyteapoptosis，and extracelular matrix（ECM）degradation.Non-codingRNA（ncRNA）participatesintheoccurrenceanddevelopment ofOAthrough theirdiverseregulatorypathways，providingnewpotentialtargetsforitstreatment.Thispapersystematicallyelucidatesthe mechanisms of ncRNA[micro ncRNA（miR），circular ncRNA（circR），and long ncRNA（IncR）] in regulating OA，as welas the current research statusoftraditional Chinesemedicine（TCM）intervening inOAbymodulatingncRNA.Itisfoundthat ncRNA participateinthepathologicalprocesssofOAbyconstructingamulti-layeredregulatorynetwork：miRinhibitsthetranslationof keytargetgenesandregulate downstreamsignaling pathways；circRcanactas‘molecularsponges’tocompetitivelyabsorbmRs forindirectregulationaswellasdirectlymodulateprotein functions；IncRpoess both‘molecularsponge’capabilitesandthe abilityto ntervene directlyin pathways.Andrograpolide，Xinfengcapsulesandothers interveneintheOA process byregulating theexpressionof miR，forminga‘TCM-miR-downstreamresponsechain’，whichreduces the expresionof matrix-hydrolyzing enzymesandinibitsthesecretionof inflammatoryfactors；paeoniflorin，Ronginniantongformulaandothers interveneintheOA process byaffectingcircRandlncR，thereby forminga‘TCM-lncR/circR-miR-downstreamresponsechain’topromotechondrocyte proliferation and reduce ECM degradation.

KEYWORDSosteoarthritis；traditional Chinese medicine；compound formula；non-coding RNA；regulatory mechanism

骨關(guān)節(jié)炎（osteoarthritis，OA）是中醫(yī)骨傷科常見病范疇，多因素交互作用使其病因復(fù)雜，病情纏綿難愈。（剩余15430字）