人工智能與群體藥動學(xué)模型在器官移植術(shù)后個體化用藥中的應(yīng)用與展望

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ABSTRACTArtificial inteligence（AI）andpopulationpharmacokinetics（PPK）technologieshavedemonstratedsignificant potentialinthepersonalizedmedicationofimmunosuppressantsafterorgantransplantation，enablingprecisepredictionofdrug dosages.ThisarticleprovidesacomprehensivereviewoftheapplicationstatusofAIandPPKintheindividualizedadministration of immunosuppessntsafterorgan transplantation，focusesonmonitoringblooddrugconcentration，predictingeficacy/adverse reactions，andestablishingindividualizeddosingmodelsfororgantransplantrecipientsafterimmunosuppessntadministration，and analyzesandcomparestheappicationcharactersticsofdiferentmethodsindiferentorgantransplantpatientsaswellasthe integrationand futuredevelopmentofAIandPPKtechnologies.AIandPPKtechnologiescannotonlysignificantlyreducethe dependenceonhumanresources，butalsogreatlyimprovethelevelof individualizedtreatmentofimmunosuppresantsafterorgan transplantation，and reduce the discomfortand burdencausedby frequent bloodconcentrationmonitoring topatients.

KEYWORDSartificial intelligence；population pharmacokinetics；organ transplantation； indiviualized medication

器官移植是治療多種終末期臟器疾病的重要手段。（剩余15037字）