代謝組學(xué)在單細(xì)胞領(lǐng)域應(yīng)用的研究進(jìn)展

［摘要］

單細(xì)胞代謝組學(xué)（SCM）是以高通量檢測和數(shù)據(jù)處理為手段，以組群指標(biāo)分析為基礎(chǔ)，以信息建模和系統(tǒng)集成為目標(biāo)，對特定生理時期的某種細(xì)胞的所有小分子量代謝物進(jìn)行定量和定性分析。本文綜述了近年來代謝組學(xué)在單細(xì)胞領(lǐng)域中的研究及應(yīng)用進(jìn)展，并對其在醫(yī)學(xué)領(lǐng)域的最新應(yīng)用進(jìn)行了詳細(xì)的討論。

［關(guān)鍵詞］ 代謝組學(xué)；高通量篩選分析；顯微鏡檢查，原子力；流式細(xì)胞術(shù)；綜述

［中圖分類號］ R34;R446-33

［文獻(xiàn)標(biāo)志碼］ A

［文章編號］ 2096-5532（2023）06-0941-04

doi：10.11712/jms.2096-5532.2023.59.186

［網(wǎng)絡(luò)出版］ https：//link.cnki.net/urlid/37.1517.R.20231229.1009.002;2024-01-02 10：45：53

RESEARCH ADVANCES IN THE APPLICATION OF METABOLOMICS IN THE FIELD OF SINGLE-CELL ANALYSIS

LUAN Ruixue， LI Lei， YI Shuyuan， LI Yunqi， WANG Shoushi

（School of Anesthesiology， Weifang Medical College， Weifang 261053， China）

; ［ABSTRACT］Single-cell metabolomics is a quantitative and qualitative analysis of all low molecular weight metabolites wi-

thin a certain type of cells at a specific physiological status， through high-throughput detection and data processing of sets of indicators for information modeling and system integration. This article reviews the research and application progress of metabolomics in the field of single-cell analysis in recent years， focusing on its latest application in the medical field.

［KEY WORDS］metabolomics; high-throughput screening assays; microscopy， atomic force; flow cytometry; reviews

代謝組學(xué)可以檢測到所有的小分子，更具體地說，是分子量小于2 000的化學(xué)物質(zhì)［1-2］。（剩余13406字）