阿爾茨海默病發(fā)病機制的研究進展

［摘 要］ 隨著我國人口老齡化問題的日趨嚴重，與衰老密切相關(guān)的老年癡呆人數(shù)也不斷增長，阿爾茨海默?。ˋD）是引起老年癡呆最常見的病因，對患者及家庭造成了嚴重的經(jīng)濟和精神負擔(dān)，因此對于腦衰老及AD的研究已經(jīng)成為迫切需求。本文就近年來AD的發(fā)病機制進行綜述，為腦衰老造成的神經(jīng)退行性AD等疾病提供參考。

［關(guān)鍵詞］ 腦衰老；發(fā)病機制；神經(jīng)退行性疾??；阿爾茨海默病  doi：10.3969/j.issn.1674-7593.2024.05.021

Advancements in the Pathogenesis Research of Alzheimers Disease

Lu Xi 1，Luo Xiaofeng 2，Song Yu 3，Liu Yongchao 1，Sun Xin 3，Li Chunying2**1 Medical Technology College of  Beihua University， Jilin 132000；2 Basic Medical College， Jilin Medical University，Jilin 132000； 3College of Pharmacy， Jilin Medical University， Jilin 132000

**Corresponding author：Li Chunying，email： lcythunder@163.com

［Abstract］ With Chinas aging population on the rise， the incidence of senile dementia， particularly neurodegenerative diseases Alzheimers disease （AD）， is also increasing， leading to significant economic and emotional burdens for patients and their families.Consequently， research on brain senescence and AD has become imperative.This review delves into recent advancements in understanding the pathogenesis of AD， offering crucial insights into the neurodegenerative processes associated with brain senescence and informing strategies for managing and treating AD and related conditions.

［Key words］ Brain senescence;Pathogenesis;Neurodegenerative diseases; Alzheimers disease

我國老年人口基數(shù)大，2020年65歲及以上的老年人口達到1.91億，2022年的老齡化率達到14%，預(yù)測2030年前后將達到20%［1］。（剩余15619字）