線(xiàn)粒體途徑凋亡及中醫(yī)藥應(yīng)用在帕金森病中的研究進(jìn)展

［摘要］帕金森?。≒D）是一種神經(jīng)系統(tǒng)退行性疾病，病程長(zhǎng)、易復(fù)發(fā)?？蓪?dǎo)致肌力、姿勢(shì)、步態(tài)及精神等異常，繼而引發(fā)殘疾。線(xiàn)粒體途徑的細(xì)胞凋亡是導(dǎo)致PD發(fā)病的重要的可能因素，本文對(duì)線(xiàn)粒體途徑凋亡與PD的關(guān)系、中醫(yī)藥對(duì)PD病機(jī)的探討及其治療作用作一綜述，探索中醫(yī)藥對(duì)于PD的有效治療手段。

［關(guān)鍵詞］帕金森?。痪€(xiàn)粒體凋亡；中醫(yī)藥應(yīng)用

doi：10.3969/j.issn.1674-7593.2023.04.021

ResearchProgressonMitochondrialPathwayApoptosisandApplicationsofTraditionalChineseMedicineinParkinson'sDisease

WangLei1，LiuDeshui2，ZhangYingbo2，ZhangXiaojie1，2，3**

1BasicMedicalCollege，HeilongjiangUniversityofChineseMedicine，Harbin150006;2DepartmentofPathology，QiqiharMedicalUniversity，Qiqihar161003;3HeilongjiangNursingCollege，Harbin150086

**Correspondingauthor：ZhangXiaojie，email：zxj4456@sina.com

［Abstract］Parkinson'sdisease（PD）isaprevalentneurodegenerativedisordercharacterizedbyachronicandrelapsingcourse.PDgivesrisetodiversefunctionalimpairments，encompassingabnormalitiesinmusclestrength，posture，gait，andmentalwell-being，oftenleadingtodisability.TheinvolvementofmitochondrialapoptosisholdssignificantrelevanceinthepathogenesisofPD.ThiscomprehensivearticleextensivelyexaminestheintricatemechanismsunderlyingPD-associatedmitochondrialpathwayapoptosis，whiledelvingintothepotentialtherapeuticstrategiesofferedbytraditionalChinesemedicine（TCM）forthemanagementofPD.ByexploringtheinterplaybetweenPDpathogenesisandTCM，thisstudyaimstoshedlightoneffectivetreatmentmodalitiesandbroadentheunderstandingofTCM'stherapeuticpotentialinPD.

［Keywords］Parkinson'sdisease;Mitochondrialapoptosis;TraditionalChinesemedicineapplication

帕金森病（Parkinson'sdisease，PD）是以中腦黑質(zhì)致密部多巴胺能（Dopaminergic，DA）神經(jīng)元的變性缺失為主要病理改變、以運(yùn)動(dòng)癥狀和非運(yùn)動(dòng)癥狀為主要表現(xiàn)的全球第二大神經(jīng)系統(tǒng)退行性疾病，起病隱匿，進(jìn)展緩慢［1-2］。（剩余7291字）