基于2005一2018年NHANES數(shù)據(jù)分析胰島素抵抗代謝評(píng)分指數(shù)與美國人膀胱過度活動(dòng)癥的關(guān)系

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Relationship between metabolic score for insulin resistance and overactive bladder in the US population based on NHANES data from 20o5 to 2018

XU Guoliang，GAO Feiyang，WANG Xihao，ZHU Jiangtao，LIN Wei，LIU Pengyue，YAN Yongjun （Department of Urology，The First Afiliated Hospital of Henan University，Kaifeng 47500o，China）

ABSTRACT：ObjectiveTo assessthe association between the metabolic score for insulin resistance index （METS-R）and overactive bladder（OAB）inthe US population，soas toexplore the potentialofMETS-IR as a predictive toolfor OABrisk and to provide insights forearlyscrening and intervention strategies.MethodsBasedonthedata fromtheNational Health and Nutrition Examination Survey （NHANES） 2005-2018 ，a cross-sectional design was employed，and multivariate logistic regresion models were used to analyze the association between METS-IR and OAB.METS-IR was analyzed both as a continuous variableandcategorized intoquartiles.Tofurthervalidatetheassociation between METS-IRand OABacro diversepopulations，subgroupanalyses wereconductedinparticipants stratifiedbyclinicalcharacteristics.Smooth curve fiting was employed to testthe linearityof the METS-IR-OABrelationship.ResultsElevated METS-IR wasasociated withan increased risk of OAB （ P<0.001 ，and this positive correlation remained stable when METS-IR was categorized into quartiles （ P<0.001） .Subgroup analyses revealed that the asociation between METS-IR and OAB was more pronounced in females， participants younger than 55 years，and non-diabetic individuals （ P<0.05? ）. Furthermore，smooth curve fitting confirmed a linear postivecorelationbetween METs-IRandOAB，withthis linearrelationshipobservedinbothdiabeticandnon-diabetic groups.ConclusionThis study，based on the NHANES 2005-2018 database，found a linear positive correlation between METS-IR and OAB.

KEY WORDS： metabolic score for insulin resistance index；overactive bladder;NHANES database；insulinresistance; metabolic syndrome

摘要：目的評(píng)估胰島素抵抗代謝評(píng)分指數(shù)（METS-IR）與膀胱過度活動(dòng)癥（OAB）之間的關(guān)系，探討 METS-IR作為OAB 風(fēng)險(xiǎn)預(yù)測工具的潛在價(jià)值，為OAB的早期篩查和干預(yù)提供參考。（剩余15215字）