TGFBR1在肝癌中的表達和對肝癌細胞活性的影響

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中圖分類號：R735.7 文獻標志碼：A 文章編號：1672-1098（2025）02-0100-09

引文格式：，.TGFBR1在肝癌中的表達和對肝癌細胞活性的影響[J].理工大學學報（自然科學版），2025，45（2） ：100-108.

DOI：10.3969/j. issn.1672-1098.2025.02.013

Expression of TGFBR1 in Hepatocellular Carcinoma and Its Impact on Tumor Cell Activity LIU Xinkuang1 ，HUANG Xiaolong

（1.TheFirstHospitalofAnuiUniversityfSienceandTechnology，HuainanAnhui220o，China;2.SchoolofMedicine，Ahi Universityof Science and Technology，Huainan Anhui 232OO1，China）

Abstract： Objective To examine TGFBR1 expression in hepatocellular carcinoma （HCC）and its clinicopathological correlations，as well as validate TGF- β pathway effects on proliferation，migration and invasion.Methods TGFBR1 expression in 25 HCC tisues，from the patients who underwent hepatectomy at the first Anhui University of Technologyafiliated hospital，was assessed via immunohistochemistry.Statistical analyses linked expressionlevels to clinical features. EdU，Transwell，and scratch assays evaluated TGF- β pathway effects. Results TGFBR1 was higher in HCC than that in normal liver tissues （ P<0.05） ），correlating with TNM stage，AFP，ALT，and AST （20 （P<0.05）.TGF-β activation enhanced HCC cell proliferation，migration and invasion. Conclusion TGFBR1 is associated with HCC progression and liver dysfunction，and therefore the research may ofer therapeutic potential for patients with liver cancer.

KeyWords：Transforming growth factorbeta receptorsI（TGFBR1）;hepatocelularcarcinoma;Immunohistochemistry;prolifera tion;migration

肝細胞癌（Hepatocellular carcinoma，HCC）是全球癌癥死亡的主要原因之一[1-2]。（剩余10262字）