鐵死亡在鼻咽癌發(fā)生發(fā)展及治療中的研究進(jìn)展

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中圖分類號(hào)：R739.6 文獻(xiàn)標(biāo)志碼：A 文章編號(hào)： 1000-5013（2025）04-0361-08

Research Progress of Ferroptosis in Pathogenesis and Therapy of Nasopharyngeal Carcinoma

WANG Fucai，ZHOU Zhihan，MA Lihao （School ofMedicine，Huaqiao University，Quanzhou 362o21，China）

Abstract：By reviewing the relevant literature in recent years，the concept，characteristics and research pro gress of ferroptosis in the treatment of nasopharyngeal carcinoma were reviewed. The results showed that the mechanism of ferroptosis was complex and it played a key role in the treatment of nasopharyngeal carcinoma. Although the long-term survival rate of nasopharyngeal carcinoma patients had significantly increased，distant metastasis and resistance to radiotherapy and chemotherapy remained the treatment diffculties for nasopharyngeal carcinoma patients. As a novel mode of celldeath characterized by elevated levels of reactive oxygen species and lipid peroxides，ferroptosis was expected to become a new target for clinical intervention in nasopharyngeal carcinoma.

Keywords：nasopharyngeal carcinoma； ferroptosis；mechanism；antibiotics resistance

鐵死亡（ferroptosis）是一種以鐵依賴性脂質(zhì)活性氧堆積為特征的細(xì)胞死亡，不同于細(xì)胞凋亡、細(xì)胞壞死和細(xì)胞自噬現(xiàn)象，是一種新型的死亡方式[1-2]。（剩余17442字）