臍帶間充質(zhì)干細胞在女性生殖系統(tǒng)疾病治療中應用的研究進展

[中圖分類號] R711.7 [文獻標志碼］A

ABSTRACTFemale reproductive system diseases， such as premature ovarian insuficiency（POI）， premature ovarian failure（POF），polycystic ovary syndrome（PCOS），intrauterine adhesions （IUA）， ulterus scar diverticulum，salpingitis，and tubal obstruction，may induce infertility，severely impacting patients’physical and mental health and quality of life. Curently，the umbilical cord mesenchymal stem cells （UCMSCs） have emerged as a research focus in gynecological and obstetric fields，demonstrating significant therapeutic potential for female reproductive system disorders. UCMSCs secrete various cytokines，activate relevant signaling pathways and key molecules，reduce inflammation mediators and oxidative stress，and prevent excessive cellular damage and apoptosis，thereby achieving therapeutic effects.In recent years，extensive studies have explored the therapeutic efects of UCMSCs on female reproductive system diseases.This article review the current in uitro and in uiuo research progress in

UCMSCs for treating female reproductive system diseases，aiming to provide the novel strategies and directions for future research and clinical applications. KEYWORDsUmbilical cord mesenchymal stem cells;；Female reproductive system diseases; Infertility；Tissue repair and regeneration；Regenerative medicine； Stem celltechnology

臍帶間充質(zhì)干細胞（umbilicalcordmesenchymalstem cells，UCMSCs）因其易于獲取、倫理爭議低和免疫原性低等特性，現(xiàn)已成為干細胞研究的熱點[1]。（剩余21005字）