氟喹諾酮類藥物增加主動(dòng)脈瘤和夾層風(fēng)險(xiǎn)的研究進(jìn)展

【摘要】主動(dòng)脈瘤（AA）和主動(dòng)脈夾層（AD）是威脅生命健康的主要疾病。氟喹諾酮類抗生素（FQ）具有重要的臨床用途和廣泛的抗菌譜。FQ可導(dǎo)致主動(dòng)脈血管破裂風(fēng)險(xiǎn)增加。FQ誘導(dǎo)AA/AD的確切機(jī)制目前尚不十分清楚?，F(xiàn)討論FQ與AA/AD之間相關(guān)性的最新研究進(jìn)展。

【關(guān)鍵詞】主動(dòng)脈瘤；主動(dòng)脈夾層；氟喹諾酮類藥物

【DOI】10.16806/j.cnki.issn.1004-3934.2023.02.013

【Abstract】Aortic aneurysm（AA） and aortic dissection （AD） are major life-threatening diseases around the world.Fluoroquinolones （FQ） remain one of the most important kind of antibiotics and have a wider clinical use and broad antibacterial spectrum.FQ was warned about an increased risk of ruptures in the aorta blood vessel in certain patients.The exact mechanism of FQ-induced AA/AD remains unclear.This review aims to the latest research progress of the alarming association between FQ and AA/AD.

【Key words】Aortic aneurysm; Aortic dissection; Fluoroquinolones

氟喹諾酮類藥物（fluoroquinolones，F(xiàn)Q）是臨床工作中最常用的抗生素之一，研究［1-3］顯示其可能與急性主動(dòng)脈瘤（aortic aneurysm，AA）和主動(dòng)脈夾層（aortic dissection，AD）有關(guān)，F(xiàn)Q的使用可增加AA/AD的發(fā)病風(fēng)險(xiǎn)。（剩余9240字）