脂質(zhì)代謝異常與抑郁癥發(fā)展的關(guān)聯(lián)及機(jī)制研究進(jìn)展

【關(guān)鍵詞】抑郁癥；脂類代謝；機(jī)制； α- 突觸核蛋白；多不飽和脂肪酸【中圖分類號(hào)】R749.41R349.11【文獻(xiàn)標(biāo)識(shí)碼】A DOI：10.12114/j.issn.1007-9572.2024.0233

【Abstract】Lipid metabolism isakeyphysiological process in the human body，anditsdisruption is closelyomected with thensetandevelopmentofepression.Nevertheless，asystematiccolltionofteseassiationsiscurrentlideate. Thisarticlecomprehensivelyexploredthechangesinlipidmetabolisminpatientswithdepresionandelaboratesondisordersin whichdisordersoflipidmetabolismwereco-morbidlyassociatedwithdepresion，suchasoverweight，obesityndmetabolic syndrome.Inaddition，thearticlesummarisedfiveintrinsic mechanisms bywhichabnormalities in lipid metabolism were asociated with the development of depression：overexpression of SNCA genes and abnormal accumulation of α -Syn，iron death，dysbiosisof gutmicrobiota，impairmentoftochondrialqualitycontrolsystems，andchroicstress.Finally，thisarticle suggestedfutureresearchdirectionsaimedatprovidinganewperspectiveandresearchbasisfortheearlydiagnosisandtreatment of depression.

【Key words】 Depression；Lipid metabolism；Mechanism；Alpha-synuclein；Polyunsaturated fatty acids

抑郁癥是一種嚴(yán)重的心理健康障礙，特征包括情緒低落、興趣缺失、睡眠障礙等，嚴(yán)重干擾個(gè)人的日常功能和生活質(zhì)量，甚至可能導(dǎo)致自殺。（剩余21243字）