卵巢高鈣血癥型小細(xì)胞癌臨床病理學(xué)分析及文獻(xiàn)回顧

Clinicopathological study on ovarain small cell carcinoma hypercalcemic- typeWang Peng，Zhang Guowen，LiXianlong，LiFei，ZhangPengnian，YangYanxia.“ ， ，

【Abstract】ObjectiveSmall cell carcinoma the ovary hypercalcemia type （SCCOHT） isa rare gynecological highly malignant tumor thatis more common inyoung women.Basedonanewlydiagnosed patient inour hospital，theclinicaland pathologicalcharacteristics SCCOHTwereanalyzed，and thepathologicaldiagnosisand research progress were reviewed through a literature review.MethodsA retrospective analysis was performed on thediagnosisand treatmentarecent SCCOHTpatientadmited toour hospitaland 57patients inthe literature， andtheclinicopathological characteristicsandresearch progress this tumorinthe literaturewere summarized. ResultsPrimary hypercalcemicsmallcell carcinoma the ovary was most common in young women，with an average age 24 years.The prognosis was poor and the survival time was1＼～2 years.The main clinical manifestations wereabdominal pain，pelvic space-occupying lesions，normal or increasedblood calcium level，and diffsesmall cell infiltrationwith local glandular，follcularand large cellcomponents.Epithelial membrane antigen （EMA），Vimentin， Calretine，Wilms Tumor 1（WT-1）positive，Brahma-related gene1（SMARCA4） negative， genetic testing was ten accompanied by SMARCA4 deletion.ConclusionSCCOHT has a relatively young onset age，extremely high malignancy，extremelypoorprognosis，and dificultpathological diagnosis.Theabsence specific SMARCA4 gene testing is helpful for diagnosis.Surgical treatment combined with adjuvant chemotherapy is the first-line treatment plan，and thepelvicand abdominal cavities arethe most common sites metastasis and recurrence.The prospects targeted therapy and immunotherapy require more clinical evidence.

【Key words】 Ovarian neoplasms；Carcinoma，small cell；Hypercalcemia

卵巢高鈣血癥型小細(xì)胞癌（smallcellcarcinomaovaryhypercalcemictype，SCCOHT）是一種臨床罕見原發(fā)于卵巢的高度惡性腫瘤，由Scully于1979年首次報(bào)道，組織學(xué)來源尚不明確，不屬于神經(jīng)內(nèi)分泌腫瘤家族，常伴有血鈣、血磷升高。（剩余10185字）