重癥肺炎患者中性粒細胞降鈣素原對病情嚴重程度的預測及列線圖分析

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Prediction of severityof illnessby nCD64 and PCT in patients with severe pneumoniaand analysis of columnchartsNiu Tairan.Department of Critical Care Medicine，Nanyang Hospital of Traditional Chinese Medicine，Henan47300o，China

【Abstract】ObjectiveTo study the value of neutrophil CD64 （nCD64）and procalcitonin （PCT） in predicting theseverityof diseaseinpatients with severepneumonia.MethodsNinety-six patientswith pneumonia received inour hospital from January 2O23to December 2O23wereretrospectivelyselectedand divided into mild andsevere groupsaccording to theseverity of the disease，and both groups were tested for the levels of nCD64 and PCT.Pearson's correlation analys was chosen toanalyze thecorrelation betweennCD64，PCTand the severity of thedisease，and the valueof nCD64，PCTand disease severity wasanalyzedbyplotting the column linegraph，calibration curveand the working characteristic curve of thesubjects（ROC）toanalyze thevalue of nCD64，PCTin predicting diseaseseverity.ResultsAtotal of 96patientswith pneumonia were included in this paper，among which 19 cases of severe pneumonia were included in the severe group，and the remaining 77 cases were included in the mild group.The levelsof nCD64 andPCTwere higher in theseveregroup than in the mild group （ P <0.05）.By constructing a column-line graph model for predicting the severity of pneumonia patients and drawing a calibration curve at thesame time，it was found thatthecalibration curve of the column-line graph model for predicting the severity of pneumonia patients was close to the ideal curve.nCD64and PCT had some predictive value in the severity of disease，especially the joint prediction corresponded to an AUC（95%CI）） value was 0.960 （O.904，1.O16），implying a higher value for joint prediction of disease severity （ P <0.05）. Conclusion The levels of nCD64 and PCT showed high expresion in patients with severe pneumonia，especially the value of thecombinationofthetwo in predicting theseverityof thedisease inpatientswith pneumonia ishigh，which can guide subsequent diagnosis and treatment.

【Key words】 Neutropenia; Pneumonia; Procalcitonin; Respiratory tract disease

重癥肺炎作為臨床較常見的呼吸系統(tǒng)疾病，其病因較復雜，使患者出現(xiàn)咳嗽、發(fā)熱、呼吸困難等癥狀，同時具備病情發(fā)展速度快、病情嚴重、并發(fā)癥較多等特點，若未及時采取有效干預措施，嚴重者可出現(xiàn)多器官功能衰竭，直接影響患者身心健康。（剩余5428字）