姜黃素抗抑郁作用機制的研究進展

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中圖分類號R285；R965 文獻標志碼A 文章編號1001-0408（2025）09-1147-06

DOI 10.6039/j.issn.1001-0408.2025.09.22

ABSTRACTCurcumin is anatural yellwpigment，anatural phenolic antioxidant extractedfromtherhizomesof Curcuma longa andCurcumaeRhizomaofthegingerfamily，withanti-inflammatory，anti-tumorandantioxidant properties.Inrcentyears，ithas beenfoundthatcurcuminalsohasgoodantidepressantproperties，nditisconsideredasafeandefectiveantidepressntpotential drug.Themechanismofcurcumin'santidepressanteficacymainlyincludesregulatingneurotransmiters，modulatingthe hypothalamic-pitaryadrealaxis，egulatingbaidriedeurotropicctoribiinguroflammationibiigidatie stress，andregulatinggutmicrobiota，etc.andthereisanoverlappngandsynergistictherapeuticefectoftheabove mehanisms. Atpresent，theantidepressantmechanismofcurcuminisstillnotfullyunderstod，andwillbecombinedwithmulti-omics technology，new formulation technology，and clinical trials to obtain further breakthroughs in the future.

KEYWORDS curcumin；depression；neurotransmitter；inflammatory response；oxidative stress；mechanism

抑郁癥是一種臨床常見的慢性、復發(fā)性精神疾病，嚴重影響患者的生活質量，甚至增加了死亡風險。（剩余14139字）