經(jīng)皮去腎神經(jīng)術(shù)：最新證據(jù)與患者篩選

【摘要】盡管有許多藥物和非藥物治療可降低血壓，但難治性高血壓仍是一個(gè)重要的健康問題。經(jīng)皮去腎神經(jīng)術(shù)（RDN）已成為有發(fā)展前景、臨床證據(jù)最多的用于改善血壓、提高血壓控制率的器械治療方法?，F(xiàn)總結(jié)目前RDN治療高血壓的機(jī)制，同時(shí)總結(jié)關(guān)于RDN的多項(xiàng)隨機(jī)假手術(shù)對照的臨床研究和優(yōu)化患者選擇。

【關(guān)鍵詞】高血壓；交感神經(jīng)系統(tǒng)；去腎神經(jīng)術(shù)

【DOI】10.16806/j.cnki.issn.1004-3934.2024.03.005

Percutaneous Renal Denervation：Latest Evidence and Patient Selection

LI Yue，LU Chengzhi

（Tianjin First Central Hospital，Tianjin 300000，China）

【Abstract】Despite the existence of numerous pharmacological and non-pharmacological interventions for lowering blood pressure，refractory hypertension persists as a significant health concern.Renal denervation（RDN） has become a promising and clinically proven instrument therapy method for improving blood pressure and increasing blood pressure control.This review summarizes the current understanding of the mechanisms behind RDN in treating hypertension and provides an overview of several randomized sham-controlled clinical studies on RDN，as well as optimization of patient selection.

【Keywords】Hypertension；Sympathetic nervous system；Renal denervation

多年來，交感神經(jīng)系統(tǒng)與心血管疾病之間的關(guān)系早已為人所知，相關(guān)研究［1-3］探討了交感神經(jīng)系統(tǒng)活性增加與難治性高血壓之間的聯(lián)系。（剩余13966字）