血清神經(jīng)元特異性烯醇化酶 癌胚抗原 鱗癌相關(guān)抗原糖類抗原125及細(xì)胞角蛋白19的可溶性片段在肺癌診斷中的應(yīng)用價(jià)值

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Application value of serum NSE， CEA，SCCAg， CA125，and CYFRA21-1 detection in the diagnosis of lung cancerLiRu.DepartmentofLaboratory，ZhoukouPeople'sHospital，Henan466ooo，China

【Abstract】ObjectiveTo explore the diagnostic value of detecting neuron-specific enolase（NSE），carcinoembryonic antigen（CEA），squamous cell carcinoma - associatedantigen （SCCAg），carbohydrate antigen 125 （CA125），and soluble fragments of cytokeratin19（CYFRA21-1） in lungcancer.MethodsA total of 78 lung cancer patientswhoreceived treatment at Zhoukou People'sHospital from July 202O to August 2023 were includedin thelung cancer group.Forty patients with benign lung lesions during thesame period were selected as thebenign group，and 3O healthy individualswho underwent physical examinations were selected as thecontrol group.Venous blood samples were collected to measure serum levels of NSE，CEA，SCCAg，CA125，and CYFRA21-1.Compare the levels of various serum tumor markers between two groupsand diferent types of lung cancer patients，and analyze the diagnosticvalueof single and combined detection of each indicator in lung cancer.ResultsCompared with the control group，the levels of various serum tumor markers were higher in both the lung cancer group and the benign group，and the lung cancer group was higher than the benign group （ P <0.05）. Compared with the control group，patients with lungadenocarcinoma，lung squamous cell carcinoma，andsmall cell lung cancer had higher levels of serumtumor markers.The levelsof NSEandCA125 insmallcellung cancer patients werehigher than thosein lungsquamous cell carcinoma and lung adenocarcinoma，while the levelsof CEA，SCCAg，and CYFRA21-1 were lower than those in lung squamous cellcarcinoma and lung adenocarcinoma （ P <0.05）.Thereceiveroperator characteristic curve （ROC）showed thatcombined detection had the highest diagnostic value in lung cancer，with thearea under thecurve （AUC）of0.924，sensitivityof0.949andspecificityof0.750.It was followed by NSE，SCCAg，CYFRA21-1，CEA and CA125.ConclusionIn the diagnosis of lung cancer，the combined detection of variousserum tumor markers has high clinical aplication value，and thecombined detection of multiple serum tumor markers can becombined in clinical diagnosis to improve the diagnostic efficiency of lung cancer， which is of great significance for evaluating the prognosis of patients.

肺癌現(xiàn)已成為威脅人類生命安全的嚴(yán)重疾病具有較高的發(fā)病率及死亡率，若早期得到不及時(shí)有效的診斷與治療，當(dāng)病情進(jìn)展至中晚期時(shí)，將對患者生命安全造成威脅，導(dǎo)致不良預(yù)后[12]。（剩余5625字）